ISO 20776-1:2006 describes one reference method, broth microdilution, for determination of MICs. The MIC reflects the activity of the drug under the described test conditions, and can be interpreted for clinical management purposes by taking into account other factors, such as drug pharmacology or bacterial resistance mechanisms. This allows categorization of bacteria as susceptible (S), intermediate (I), or resistant (R). In addition, MIC distributions can be used to define wild type or non-wild type bacterial populations. Although clinical interpretation of the MIC value is beyond the scope of ISO 20776-1:2006, modifications of the basic method are required for certain antimicrobial agent - bacteria combinations to facilitate clinical interpretation. These modifications are included in a separate table. It is advisable to compare other susceptibility testing methods (e.g. routine methods or diagnostic test devices) with this reference method for validation, in order to ensure comparable and reliable results.
Status: WithdrawnPublication date: 2006-11
Corrected version (fr): 2007-02
Edition: 1Number of pages: 19
Technical Committee: ISO/TC 212 Clinical laboratory testing and in vitro diagnostic test systems
- ICS :
- 11.100.20 Biological evaluation of medical devices
ISO 20776-1:2006Stage: 95.99
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